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Clear Your Mind - Blog


Stimulation of platelet serotonin transport by substituted 1,4-naphthoquinone-induced oxidant stress
Abstract The effect of oxidant stress produced by redox cycling of substituted 1,4-naphthoquinones on the activity of platelet...

Martin Mattsson
Jan 161 min read
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Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO
Abstract Monoamine oxidase (MAO) catalyzes the oxidative deamination of biogenic and exogenous amines and its inhibitors have therapeutic...

Martin Mattsson
Jan 161 min read
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Effects of orally administered glycine on myofibrillar proteolysis and expression of proteolytic-related genes of skeletal muscle in chicks
Abstract We examined the effects of orally administered glycine on myofibrillar proteolysis in food-deprived chicks. Food-deprived (24 h)...

Martin Mattsson
Jan 161 min read
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Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis
Abstract Osteoporosis is a disease of low bone mass most often caused by an increase in bone resorption that is not sufficiently...

Martin Mattsson
Jan 161 min read
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Inhibition of tryptophan hydroxylase abolishes fatigue induced by central tryptophan in exercising rats
Abstract Fatigue during prolonged exercise is related to brain monoamines concentrations, but the mechanisms underlying this relationship...

Martin Mattsson
Jan 161 min read
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High Fat Diet Alters Lactation Outcomes: Possible Involvement of Inflammatory and Serotonergic Pathways
Abstract Delay in the onset of lactogenesis has been shown to occur in women who are obese, however the mechanism altered within the...

Martin Mattsson
Jan 167 min read
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Aspirin curtails the acetaminophen-induced rise in brain norepinephrine levels
Abstract We previously showed that acetaminophen administration to rats increases forebrain serotonin levels as a result of the...

Martin Mattsson
Jan 161 min read
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Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels
Abstract Pulmonary arterial hypertension (PAH) is characterized by increasing pulmonary pressure, right ventricular failure, and death....

Martin Mattsson
Jan 161 min read
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Activation of Meningeal 5-HT2B Receptors: An Early Step in the Generation of Migraine Headache?
Abstract Several pharmaceuticals are frequently dispensed to prevent or reduce the occurrence of migraine attacks. The prophylactic...

Martin Mattsson
Jan 161 min read
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Preventive effect of cyproheptadine hydrochloride in refractory patients with frequent migraine
Abstract Cyproheptadine hydrochloride (CH) is rarely used to treat adult patients with migraine in Japan because it causes sleepiness. In...

Martin Mattsson
Jan 161 min read
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Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice
Abstract The inhibition of sensory responsivity is considered a core serotonin function, yet this hypothesis lacks direct support due to...

Martin Mattsson
Jan 1614 min read
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Lost memories might be able to be restored, new UCLA study indicates
New UCLA research indicates that lost memories can be restored. The findings offer some hope for patients in the early stages of...

Martin Mattsson
Jan 165 min read
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Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia
Abstract Long-term memory (LTM) is believed to be stored in the brain as changes in synaptic connections. Here, we show that LTM storage...

Martin Mattsson
Jan 1626 min read
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Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response
Abstract The role of serotonin in depression and antidepressant treatment remains unresolved despite decades of research. In this paper,...

Martin Mattsson
Jan 168 min read
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Science behind commonly used anti-depressants appears to be backwards, researchers say
The science behind many anti-depressant medications appears to be backwards, say the authors of a paper that challenges the prevailing...

Martin Mattsson
Jan 162 min read
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Serotonin deficiency? Study throws into question long-held belief about depression
New evidence puts into doubt the long-standing belief that a deficiency in serotonin -- a chemical messenger in the brain -- plays a...

Martin Mattsson
Jan 162 min read
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Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype
Abstract Reductions in function within the serotonin (5HT) neuronal system have long been proposed as etiological factors in depression....

Martin Mattsson
Jan 161 min read
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An antidepressant that extends lifespan in adult Caenorhabditis elegant
Abstract The mechanisms that determine the lifespan of an organism are still largely a mystery 1 . One goal of ageing research is to find...

Martin Mattsson
Jan 161 min read
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An antidepressant that extends lifespan in adult Caenorhabditis elegans
The mechanisms that determine the lifespan of an organism are still largely a mystery. One goal of ageing research is to find drugs that...

Martin Mattsson
Jan 161 min read
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The Role of Serotonin (5-HT) in Behavioral Control: Findings from Animal Research and Clinical Implications
Abstract The neurotransmitters serotonin and dopamine both have a critical role in the underlying neurobiology of different behaviors....

Martin Mattsson
Jan 146 min read
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